Limb-girdle muscular dystrophy is a term used to describe a group of diseases that cause weakness and wasting of the muscles in the arms and legs. The muscles most affected are those closest to the body, specifically the muscles of the shoulders, upper arms, pelvic area, thighs, and, occasionally, the heart. LGMD2C is one of the more severe kinds of LGMD, frequently impacting children at a young age. This page provides details about limb-girdle muscular dystrophy type 2C.
Muscular dystrophy is a group of hereditary muscle diseases and limb-girdle muscular dystrophies are those in which the muscles most severely affected are the hip and shoulder muscles, the so-called “limb girdle muscles.”
Limb-girdle muscular dystrophy type 2C (“LGMD2C”) is a more severe limb-girdle muscular dystrophy and is one of the two or three most severe muscular dystrophies. Children with LGMD2C cannot produce a protein, gamma sarcoglycan, necessary for muscle strength and function. Instead of muscles growing stronger after exercise, muscles deteriorate. Although children with LGMD2C like Kurt and Peter are able to live normally at young ages, over time their deteriorating muscles prevent them from engaging in a number of typical childhood activities. The disease is highly variable. Many children with LGMD2C are in a wheelchair in their mid-to-late teenage years.